|
rs4647269
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs1800734 and rs4647269 in MLH1 were found to be significantly different between severe oligozoospermia and control groups (p < 0.05).
|
31342644 |
2019 |
|
rs10842262
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that rs12097821 and rs10842262 were strongly associated with the risk of NOA but not total male infertility or oligozoospermia, while rs2477686 and rs6080550 were not associated with the risk of total male infertility, NOA, or oligozoospermia.
|
30863997 |
2019 |
|
rs1800734
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1800734 and rs4647269 in MLH1 were found to be significantly different between severe oligozoospermia and control groups (p < 0.05).
|
31342644 |
2019 |
|
rs2477686
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that rs12097821 and rs10842262 were strongly associated with the risk of NOA but not total male infertility or oligozoospermia, while rs2477686 and rs6080550 were not associated with the risk of total male infertility, NOA, or oligozoospermia.
|
30863997 |
2019 |
|
rs2656927
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, the genotype frequencies of SNP rs2656927 (P = 0.014) and rs8103849 (P < 0.001) significantly differed between men with oligozoospermia in case group 1 and normozoospermic men.
|
31802345 |
2019 |
|
rs6080550
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that rs12097821 and rs10842262 were strongly associated with the risk of NOA but not total male infertility or oligozoospermia, while rs2477686 and rs6080550 were not associated with the risk of total male infertility, NOA, or oligozoospermia.
|
30863997 |
2019 |
|
rs8103849
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, the genotype frequencies of SNP rs2656927 (P = 0.014) and rs8103849 (P < 0.001) significantly differed between men with oligozoospermia in case group 1 and normozoospermic men.
|
31802345 |
2019 |
|
rs12870438
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Of these, three SNPs (rs7867029, rs7174015, and rs12870438) were found to be significantly associated with the risk of azoospermia and/or oligozoospermia in a Japanese population.
|
28975488 |
2018 |
|
rs7174015
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Of these, three SNPs (rs7867029, rs7174015, and rs12870438) were found to be significantly associated with the risk of azoospermia and/or oligozoospermia in a Japanese population.
|
28975488 |
2018 |
|
rs10966811
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was a statistically significant association between rs12376894 proxy SNP of rs10966811 and oligozoospermia.
|
28975488 |
2018 |
|
rs12348
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When we assessed the relationship between rs12348 in TUSC1 and rs2772579 in IZUMO3 and male infertility traits, we found that rs12348 in TUSC1 was significantly associated with azoospermia and oligozoospermia, but rs2772579 in IZUMO3 was not associated with male infertility.
|
28975488 |
2018 |
|
rs12376894
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was a statistically significant association between rs12376894 proxy SNP of rs10966811 and oligozoospermia.
|
28975488 |
2018 |
|
rs202007462
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both groups showed nearly identical distributions of the SOAT-L204F polymorphism (∼10% heterozygous and ∼5% homozygous), indicating that this polymorphism seems not be causative for hypospermatogenesis.
|
28951225 |
2018 |
|
rs61734716
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both groups showed nearly identical distributions of the SOAT-L204F polymorphism (∼10% heterozygous and ∼5% homozygous), indicating that this polymorphism seems not be causative for hypospermatogenesis.
|
28951225 |
2018 |
|
rs144944885
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As a result, the 50776482 delC intronic variant (rs144944885) was identified in five patients with oligoasthenoteratozoospermia defect and one patient with ISTS defect in heterozygote form.
|
28138870 |
2017 |
|
rs886039769
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The father of the patients showed oligozoospermia with the p.R92W mutation, suggesting that in 46,XY individuals, the mutation would cause various gonadal phenotypes.
|
29393271 |
2017 |
|
rs147894843
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Other variants identified in SEMGs possibly contributing to hyperviscosity and asthenozoospermia consisted of three replacements predicted to modify targets of proteolysis (P = 0.0442 for SEMG1 p.Gly400Asp) and a copy number variation associated with a reduced risk of oligozoospermia (P = 0.0293).
|
27827323 |
2016 |
|
rs16895863
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant difference between the oligospermia men (oligospermia group) and the fertile men (control group) was observed in this research (odds ratio [OR]: 2.764; 95% CI: 95% confidence interval [CI]: 1.171-6.525; P = 0.017), which could indicate that the combined AT-TC-CC genotype in the UBR2 gene (rs16895863, rs373341, rs3749897 respectively) is a possible risk of idiopathic oligospermia for men in Sichuan, China.
|
26940145 |
2016 |
|
rs2274911
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Homozygous subjects for the risk allele A of rs2274911 had a 4.60-fold increased risk of oligozoospermia and 3.52-fold increased risk of cryptorchidism.
|
26735260 |
2016 |
|
rs28362491
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggested that the heterozygosity of rs28362491 in the NF-
|
27041523 |
2016 |
|
rs373341
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant difference between the oligospermia men (oligospermia group) and the fertile men (control group) was observed in this research (odds ratio [OR]: 2.764; 95% CI: 95% confidence interval [CI]: 1.171-6.525; P = 0.017), which could indicate that the combined AT-TC-CC genotype in the UBR2 gene (rs16895863, rs373341, rs3749897 respectively) is a possible risk of idiopathic oligospermia for men in Sichuan, China.
|
26940145 |
2016 |
|
rs3749897
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant difference between the oligospermia men (oligospermia group) and the fertile men (control group) was observed in this research (odds ratio [OR]: 2.764; 95% CI: 95% confidence interval [CI]: 1.171-6.525; P = 0.017), which could indicate that the combined AT-TC-CC genotype in the UBR2 gene (rs16895863, rs373341, rs3749897 respectively) is a possible risk of idiopathic oligospermia for men in Sichuan, China.
|
26940145 |
2016 |
|
rs696
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We hypothesized a possible relationship between the NF-
|
27041523 |
2016 |
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our meta-analysis showed that the MTHFR C677T mutation was a risk factor for male infertility in both azoospermia and oligoasthenoteratozoospermia patients, especially in Asian population.
|
26549413 |
2015 |
|
rs12870438
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The association between rs7174015 and oligozoospermia under a dominant model and between rs12870438 and azoospermia under additive and recessive models remained after correction for multiple testing.
|
25908656 |
2015 |